Multiple sequence alignment (program MASIA), self-correcting distance geometry calculations (DIAMOD) and energy refinement (FANTOM) can be used for de novo prediction of protein structures. In cooperation with my co-worker Hongyao Zhu we have predicted several possible 3D structures of the HIV-1 Rev protein (regulator of the expression of the type-1 human immunodeficiency virion). This protein is an essential element in the process of HIV replication. Inhibitors of the HIV protease are the most recent powerful drugs against AIDS able to diminish the virus population below the level of detection. Our work is the first step toward "Rev inhibitors", a new class of drugs that, in analogy to protease inhibitors, will interfere with the virus life cycle.