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Links Dr. Werner Braun's
Research Homepage Sealy Center for
Structural Biology and Molecular Biophysics
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The Schein Group
Research Homepage
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 The Schein Group Front: Catherine H. Schein, (Back: from left to right); Shubhra Ghosh Dastidar, Deliang Chen and Milind Misra. |
Catherine Schein with Thomas Steitz at the 13th Annual Sealy Center for Structural Biology Symposium. May 16-17, 2008. |
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- PCPMer
is a software tool for automatic motif detections of a protein family
and identifications of related family members in protein sequence
databases. (Bin Zhou, Catherine H. Schein and Werner Braun).
- Structural Biology of Allergens: Investigations regarding sequence and structural determinants of allergenicity, allergens motifs, and database mining for the identification of potential allergens (Ovidiu Ivanciuc, Catherine H. Schein, Terumi Midoro-Horiuti, Randall M Goldblum, Edward G. Brooks, Werner A. Braun).
- DNA Repair: Molecular recognition of DNA damage sites by apurinic/apyrimidinic endonucleases (Catherine H. Schein, Numan Oezguen, Tadehide Izumi, David Power, Werner A. Braun)
- FANTOM:
software for efficient molecular modeling of proteins in torsional
angle space
(Kizhake Soman and Werner Braun). - NOAH/DIAMOD, a suit of programs have been developed for automated 2D or 3D protein NOESY spectrum assignment and 3D structure determination (Yuan Xu, Numan Oezguen, Catherine H. Schein and Werner Braun).
- MASIA/DIAMOD
development:
An expert system which combines Self-Correcting Distance Geometry
calculations with a pattern recognition algorithm to model 3D
structures of protein
(Catherine H. Schein and Werner Braun). - Motif and Molego Analysis Project: Developing a GUI-interfaced program to search for consistent patterns in multiple aligned sequences. (Bin Zhou, Surendra Negi, Catherine H. Schein and Werner Braun).
- Bacillus
anthracis Project:
Sequence decomposition of the 3 toxins of B. anthracis is used to: identify
conserved residues and likely interacting protein sites, yield
conserved functional areas that differ from mammalian proteins with
similar activities and to guide design of novel inhibitors to 1)
complex formation and 2) catalytic activities
(Catherine H. Schein, David Power, Deliang Chen, Gerd Mench, Johnny W. Peterson and Werner Braun).
- MPACK is a homology modeling package that integrates several packages from our group: PCPmer to
identify conserved regions, EXDIS to
extract angle and
distance
constraints, DIAMOD to generate protein models from geometric constraints, and FANTOM to optimize the
protein geometry with the ECEPP
force field.
- SDAP is a Web server that integrates a database of allergenic proteins with various bioinformatics and computational tools to perform structural studies related to allergens and characterization of their epitopes.
- FANTOM (Energy refinement and Monte Carlo simulations of proteins).
- GETAREA (Web interface to solvent accessible surface area calculations).
- On-line Publication: Fraczkiewicz, R. and Braun, W. "A New Efficient Algorithm for Calculating Solvent Accessible Surface Areas of Macromolecules".
- MASIA (Pattern search and analysis in multiple aligned sequences of proteins).
- DIAMOD (Self-correcting distance geometry calculations of protein and DNA structures).
- NOAH (Structure-based automatic assignment of multidimensional NOESY spectra).
- PCPMer is a software tool for automatic motif detections of a protein family and identification of related family members in protein sequence database.
- InterProSurf is designed to predict the most likely sites on proteins to interact with other proteins, such as toxin elements, cell receptors and other proteins that make up virus capsids.
- Flavitrack
contains over 475 complete genomic sequences from almost 40 different
flaviviruses, as well as related information on known mutations and
literature references. In addition, each sequence has been assigned a
unique identifier, i.e., a "license plate", which summarizes its date
and place of isolation, phenotype, and lethality. This enables us to
run very large sequence alignments and interpret the data with regard
to vector and symptom specificity within viral subclasses and strain
evolution.
- Sealy Center for Structural Biology and Molecular Biophysics
- Computational
Biology Computer Center Website
- Department of
Biochemistry and Molecular Biology
- Sealy Center for Molecular Medicine
- Sealy Center for Vaccine Development
- National
Institute of Environmental Health Sciences (NIEHS) Center in
Environmental Toxicology
- Center for Biodefense and Emerging Infectious Diseases
- Department of
Neuroscience and Cell Biology
- Department
of Microbiology & Immunology
- Department of
Pharmacology & Toxicology
- Department of Pathology
- Biophysical, Structural & Computational Biology
- Department of Cellular Physiology and Molecular Biophysics
- The NMR Research Facility at UTMB
- The UTMB
Bioinformatics Service Core
- University of Texas Medical Branch