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Important Group Related
Links:
Catherin Schein's
-Faculty
Homepage
-Research Homepage
Computational
Biology Homepage
Department of
Biochemistry and
Molecular Biology
Werner Braun's
-Faculty
Homepage
-Research Homepage
Department
of
Microbiology & Immunology
Sealy Center for
Structural Biology and Molecular Biophysics
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(97) van der Heden van Noort, G.J.,
Schein, C.H., Overkleeft, H.S., van der
Marel, G.A., and Filippov, D.V. (2013)
 A General
Synthetic Method Towards Uridylylated
Picornavirus VPg Proteins.
Journal of
Peptide Science (In press).
(96) Power, T.D, Ivanciuc,
O., Schein, C.H. and Braun, W. (2013)
Assessment of
3D models for allergen research.
PROTEINS:
Struct. Funct. and Bioinf., (Proteins.
2013 Apr;81(4):545-54.).
(95) Schein, C.H., Chen, D.,
Ma, L., Kanalas, J.J., Gao, J.,
Estrella-Jimenez, M.E., Sower, L.E., Walter,
M.A., Gilbertson, S.R. and Peterson,
J.W. (2012)
Pharmacophore
selection and redesign of non-nucleotide
inhibitors of anthrax edema factor.
Toxins,
4(11), 1288-1300.
(94) Nesbit, J.B., Hurlburt,
B.K., Schein, C.H., Cheng, H., Wei, H. and
Maleki, S.J. (2012)
Ara h 1
structure is retained after roasting and is
important for enhanced binding to IgE.
Mol. Nutr. Food
Res., 56, 1-9.
(93) Bowen, D.M., Lewis,
J.A., Lu, W. and Schein, C.H.
(2012)
Simplifying
complex sequence information: a
PCP-consensus protein binds antibodies
against all four Dengue serotypes.
Vaccine,
30(42), 6081-6087.
(92) Schein, C.H., Bowen,
D.M., Lewis, J.A., Choi, K., Paul, A., van der
Heden van Noort, G.J., Lu, W. and Filippov,
D.V. (2012)
Physicochemical property consensus
sequences for functional analysis, design of
multivalent antigens and targeted
antivirals.
BMC
Bioinformatics, 13(Suppl 13):S9.
(91) Chen, D., Ma, L.,
Kanalas, J.J., Gao, J., Pawlik, J.,
Estrella-Jimenez, M.E., Walter, M.A.,
Peterson, J.W., Gilbertson, S.R. and Schein,
C.H. (2012)
Structure-Based
Redesign of an Edema Toxin Inhibitor.
Bioorg. Med.
Chem., 20(1), 368-376.
(90) Maleki, S.J., Teuber,
S.S., Cheng, H., Chen, D., Comstock,
S.S., Ruan, S. and Schein, C.H. (2011)
Computationally
Predicted IgE Epitopes of Walnut Allergens
Contribute to Cross-Reactivity with Peanuts.
Allergy,
66(12), 1522-1529.
(89) Oezguen, N., Mantha,
A.K., Izumi, T., Schein, C.H., Mitra, S. and
Braun, W. (2011)
Simulation and
Experimental Evidence for Mg2+ Binding at
the B Site in Human AP Endonuclease 1.
Bioinformation,
7(4), 184-198.
(88) Ivanciuc, O., Gendel,
S.M., Power, T.D., Schein, C.H. and Braun,
W. (2011)
AllerML: Markup
Language for Allergens.
Regul. Toxicol.
Pharmacol., 60(1), 151-160.
(87) Schein, C.H., Ivanciuc,
O., Midoro-Horiuti, T., Goldblum, R.M. and
Braun, W. (2010)
An allergen
portrait gallery: representative structures
and an overview of IgE binding surfaces.
Bioinform. Biol.
Insights, 4, 113-125.
(86) Bruce, N.J., Chen, D.,
Dastidar, S.G., Marks, G.E., Schein, C.H. and
Bryce, R.A. (2010)
Molecular
Dynamics Simulations of Aβ Fibril
Interactions with β-sheet Breaker Peptides.
Peptides,
31(11), 2100-2108.
(85) Schein, C.H., Oezguen,
N., van der Heden van Noort, G.J., Filippov,
D.V., Paul, A., Kumar, E. and Braun, W.
(2010)
NMR solution
structure of poliovirus uridylyated peptide
linked to the genome (VPgpU).
Peptides,
31(8), 1441-1448.
(84) Zhang, S., Bovshik, E.,
Maillard, R., Gromowski, G., Volk, D.E.,
Schein, C.H., Huang, C., Gorenstein, D.G.,
Lee, J., Barrett, A. and Beasley, D.W.C.
(2010)
Role of BC loop
residues in structure, function and
antigenicity of the West Nile virus envelope
protein receptor binding domain III.
Virology,
403(1), 85-91.
(83) Moen, S.T., Slater,
T.M., Patel, S.D., Tutt, C.B.,
Estrella-Jimenez, M.E., Pawlick, J., Sower,
L., Popov, V.L., Schein, C.H., Gilbertson,
S.R., Peterson, J.W. and Torres, A.G.
(2010)
Testing
efficacy and toxicity of adenylyl cyclase
inhibitors against enteric pathogens during
in vitro and in vivo models of infection.
Infect. Immun.,
78(4), 1740-1749.
(82) Danecek, P., Lu, W. and
Schein, C.H. (2010)
PCP-consensus
sequences of Flaviviruses: correlating
variance with vector competence and disease
phenotype.
J. Mol. Biol.,
396(3), 550-563.
(81) Schein, C.H.
(2010)
Soluble Protein
Expression in Bacteria.
Wiley
Encyclopedia of Industrial Biotechnology:
Bioprocess, Bioseparation, and Cell
Technology, Publ. John Wiley & Sons,
4534-4552.
(80) Schein, C.H.
(2010)
Protein
Aggregation and Precipitation, Measurement
and Control.
Wiley
Encyclopedia of Industrial Biotechnology:
Bioprocess, Bioseparation, and Cell
Technology, Publ. John Wiley & Sons,
4026-4054.
(79) Danecek, P. and Schein,
C.H. (2010)
Flavitrack
analysis of the structure and function of
West Nile non-structural proteins.
Int. J.
Bioinformatics Res. Appl., 6(2),
134-146.
(78) Chen, D., Martin, Z.S., Soto,
C. and Schein, C.H. (2009)
Computational
Selection of Inhibitors of A-beta
Aggregation and Neuronal Toxicity.
Bioorg. Med.
Chem., 17(14), 5189-5197.
(77) Ivanciuc, O.,
Schein, C.H., Garcia, T.I., Oezguen, N., Negi,
S.S. and Braun, W. (2009)
Structural
analysis of linear and conformational
epitopes of allergens.
Regul. Toxicol.
Pharmacol., 54(3 Suppl), S11-S19.
(76) Ivanciuc, O.,
Midoro-Horiuti, T., Schein, C.H., Xie, L.,
Hillman, G.R., Goldblum, R.M. and Braun,
W. (2009)
The property
index PD predicts peptides that cross-react
with IgE antibodies.
Mol. Immunol.,
46(5), 873-883.
(75) Ivanciuc, O.,
Garcia, T.I., Torres, M., Schein, C.H. and
Braun, W. (2009)
Characteristic
motifs for families of allergenic proteins.
Mol. Immunol.,
46(4), 559-568.
(74) Chen, D., Misra, M.,
Sower, L., Peterson, J.W., Kellogg, G.E. and
Schein, C.H. (2008)
Novel
inhibitors of Anthrax edema factor.
Bioorg. Med.
Chem., 16(15), 7225-7233.
(73) Oezguen, N.,
Zhou, B., Negi, S.S., Ivanciuc, O., Schein,
C.H., Labesse, G. and Braun, W. (2008)
Comprehensive
3D-modeling of allergenic proteins and amino
acid composition of potential conformational
IgE epitopes.
Mol. Immunol.,
45(14), 3740-3747.
(72) Cummins, S.F., Xie,
F., de Vries, M.R., Annangudi, S.P., Misra,
M., Degnan, B.M., Sweedler, J.V., Nagle, G.T.,
Schein, C.H. (2007)
Aplysia
temptin: the "glue" in the water-borne
attractin pheromone complex.
Febs J.,
274(20), 5425-5437.
(71) Negi, S., Schein,
C.H., Oezguen, N., Power, T.D. and Braun,
W. (2007)
InterProSurf: a
web server for predicting interacting sites
on protein surfaces.
Bioinformatics,
23(24), 3397-3399.
(70) Misra, M. and
Schein, C.H. (2007)
Flavitrack: An
annotated database of flavivirus sequences.
Bioinformatics,
23(19), 2645-2647.
(69) Sha, J., Wang, S.F.,
Suarez, G., Sierra, J.C., Fadl, A.A., Erova,
T.E., Foltz, S.M., Khajanchi, B.K., Silver,
A., Graf, J., Schein, C.H., Chopra, A.K.
(2007)
Further
characterization of a type III secretion
system (T3SS) and of a new effector protein
from a clinical isolate of Aeromonas
hydrophila-Part I.
Microb.
Pathog., 43(4), 127-146.
(68) Oezguen, N., Schein,
C.H., Peddi, S.R., Power, T.D., Izumi, T. and
Braun, W. (2007)
A
"moving metal mechanism" for substrate
cleavage by the DNA repair endonuclease
APE-1.
Proteins,
68(1),
313-323.
(67) Chen, D., Menche, G,
Power, T.D., Peterson, J.W. and Schein, C.H
. (2007)
Accounting
for
ligand-bound metal ions in docking small
molecules on adenylyl cyclase toxins.
Proteins,
67(3),
593-605.
(66) Schein, C.H.
Ivanciuc O. and Braun, W. (2007)
Bioinformatics
approaches
to classifying allergens and predicting
cross-reactivity.
Immunol.
Allergy Clin. North Am., 27(1), 1-27.
(65) Cummins, S.F., Xie,
F., Misra, M., Amare, A., Jakubowski, J.A., de
Vries, M.R., Sweedler, J.V., Nagle, G.T. and
Schein, C.H. (2007)
Recombinant
production
and structural studies of the aplysia
water-borne protein phermone enticin
indicates it has a novel disulfide
stabilized fold.
Peptides,
28(1), 94-102.
(64) Schein, C.H.,
Ivanciuc, O.and
Braun, W. (2006)
Structural
Database
of Allergenic Proteins (SDAP).
Food Allergy, Edited by S.J.
Maleki, copyright 2006
ASM Press, Washington D.C. 257-283.
(63) Negi, S.S.,
Kolokoltsov, A.A., Schein, C.H., Davey, R.A.
and Braun, W. (2006)
Determining
functionally
important amino acid residues of the E1
protein of Venezuelan equine encephalitis
visus.
J. Mol.
Model., 12(6), 921-929.
(62) Schein, C.H.,
Oezguen, N., Volk, D.E., Garimella, R., Paul,
A. and Braun, W. (2006)
NMR
structure of the viral peptide linked to the
genome (VPg) of poliovirus.
Peptides,
27(7), 1676-1684..
(61) Schein, C.H., Volk,
D.E., Oezguen, N. and Paul, A. (2006)
Novel,
structure-based mechanism for uridylylation
of the genome-linked peptide (VPg) of
picornaviruses.
Proteins, 63(4),
719-726.
(60) Cummins S.F.,
Nichols A.E., Schein C.H. and Nagle G.T.
(2006)
Newly
identified water-borne protein pheromones
interact with attractin to stimulate mate
attraction in Aplysia.
Peptides,
27(3),
597-606.
(59) Midoro-Horiuti, T.,
Schein, C.H., Mathura, V., Braun, W.,
Czerwinski, E.W., Togawa, A., Kondo, Y., Oka,
T., Watanabe, M. and Goldblum, R.M. (2006)
Structural
basis
for epitope sharing between group 1
allergens of cedar pollen.
Mol. Immunol., 43(6),
509-518.
(58) Schein, C.H., Ivanciuc, O.
and Braun, W. (2005)
Common
physical-chemical properties correlate with
similar structure of the IgE epitopes of
peanut allergens.
J. Agric. Food Chem., 53(22),
8752-8759.
(57) Schein, C.H., Zhou, B. and
Braun, W. (2005)
(56) Cummins, S.F., Schein,
C.H., Xu, Y., Braun, W. and Nagle, G.T. (2005)
Molluscan
attractins, a family of water-borne protein
pheromones with interspecific
attractiveness.
Peptides, 26, 121-129.
(55) Schein,
C.H., Zhou, B., Oezguen, N., Mathura, V.S., and Braun,
W. (2005)
Molego-based definition of the
architecture and specificity of metal
binding sites.
Proteins, 58, 200-210.
(54) Painter,
S.D., Cummins, S.F., Nichols, A.E., Akalal,
D.B.G., Schein, C.H., Braun, W., Smith, J.S.,
Susswein, A.J., Levy, M., de Boer, P.A.C.M.,
ter Maat, A., Miller, M.W., Scanlan, C.,
Milberg, R.M., Sweedler, J.V. and Nagle,
G.T. (2004)
Structural
and
functional analysis of Aplysa attractins,
a family of water-borne protein phermones
with interspecific attractiveness.
Proc. Natl.
Acad. Sci. USA, 101, 6929-6933.
(53) Ivanciuc,
O., Oezguen, N., Mathura, V.S., Schein,
C.H., Xu, Y. and Braun, W. (2004)
Using
property based sequence motifs and 3D
modeling to determine structure and
functional regions of proteins.
Curr. Med.
Chem., 11, 583-593.
(51) Izumi, T., Schein, C.H.,
Oezguen, N., Feng, Y. and Braun, W. (2004)
Effects
of backbone contacts 3' to the abasic site
on the cleavage and the product binding by
human apurinic/apyrimidinic endonuclease
(APE1).
Biochemistry, 43, 684-689.
(49) Hermann, P.M.,
Schein, C.H., Nagle, G.T. and Wildering,
W.C. (2004)
Lymnaea
EGF and gigantoxin I, novel invertebrate
member of the epidermal growth factor
family.
Curr. Pharm.
Des., 10(31):3885-3892.
(48) Akalal, D.B., Schein, C.H.
and Nagle, G.T. (2004)
Mollusk-derived
growth
factor and the new subfamily of adenosine
deaminase-related growth factors.
Curr. Pharm.
Des., 10(31):3893-3900.
(47)
Midoro-Horiuti, T., Mathura, V., Schein, C.H.,
Braun, W., Yu, S., Watanabe, M., Lee, J.C.,
Brooks, E.G. and Goldblum, R. (2003)
Major linear IgE epitopes of
mountain cedar pollen allergen Jun a 1
map to the pectate lyase catalytic site.
Mol. Immunol., 40, 555-562.
(46) Ivanciuc,
O., Mathura, V.,
Midoro-Horiuti, T., Braun, W., Goldblum, R.
and Schein, C.H. (2003)
Detecting
potential
IgE-reactive sites on food proteins using
a sequence and structure database,
SDAP-Food.
J.
Agr. Food Chem., 51, 4830-4837.
(45) Garimella,
R., Xu, Y., Schein, C.H., Rajarathnam, K.,
Painter, S.D., Nagle, G.T. and Braun, W.
(2003)
NMR
solution structure of attractin, a
water-borne protein pheromone from the
mollusk Aplysia californica.
Biochemistry, 42,
9970-9979.
(40) Murtazina,
D., Puchkaev, A.V., Schein, C.H., Oezguen, N.,
Braun, W., Nanavati, A. and Pikuleva, I.A.
(2002)
Membrane-protein
interactions
contribute to efficient 27-hydroxylation of
cholesterol by mitochondrial cytochrome P450
27A1.
J. Biol. Chem.,
277, 37582-37589.
(37) Schein, C.H., Nagle, G.T.,
Page, J. Sweedler, J.V., Xu, Y., Painter, S.D.
and Braun, W. (2001)
Aplysia
attractin: biophysical characterization and
modeling of a water-borne pheromone.
Biophys. J., 81, 463-472.
(35) Soman, K.V.,
Schein, C.H., Zhu, H. and Braun, W. (2001)
Homology
modeling
and simulations of nuclease structures.
In Nuclease
Methods and Protocols, Schein, C.H. (ed) for
series Methods in Molecular Biology
Vol. 160,
2001, Humana Press, Totowa, N.J., pp. 263-286.
(34) Midoro-Horiuti, T M.
Goldblum, R M. Schein, C H. Soman, K V. Braun,
W. Kurosky, A. Brooks, E G. (2000)
Structural Analysis of Jun a 3,
a Potentially Inducible Allergen of Mountain
Cedar Pollen.
J. Allergy Clin. Immun., 105 (1): Part 2,
S327.
(32) Soman, K.V.,
Midoro-Horiuti, T., Ferreon, J.C., Goldblum,
R.M., Brooks, E.G., Kurosky,
A., Braun, W.
and Schein, C.H. (2000).
Homology
modeling
and characterization of Ig E binding
epitopes of mountain cedar allergen Jun a 3.
Biophys. J., 79, 1601-1609.
(29) Midoro-Horiuti, T.,
Goldblum, R.M., Kurosky, A., Wood, T.G.,
Schein, C.H. and Brooks, E.G. (1999)
Molecular
cloning
of mountain cedar (Juniperus ashei) pollen
major allergen, June a 1.
J. Allergy Clin.
Immunol., 104(3 Pt 1):613-617.
(28) Schein,
C.H. (1999)
Protein expression, soluble.
For The
Encyclopedia of Bioprocess Technology:
Fermentation, Biocatalysis and Bioseparation.
J. Wiley and
Sons, New York, NY. pp 2156-2169.
(27) Schein,
C.H. (1999)
Protein aggregation,
degradation.
For
the Encyclopedia of Bioprocess Technology:
Fermentation, Biocatalysis and Bioseparation.
J. Wiley and
Sons, New York, NY. pp 2134-2155.
(22) Boix, E., Nogués,
M.V., Schein, C.H., Benner, S.A. and Cuchillo,
C.M. (1994)
Reverse
transphosphorylation by ribonuclease A needs
an intact p2 binding site. Point
mutations at Lys-7 and Arg-10 alter the
catalytic properties of the enzyme.
J. Biol. Chem.,
269,
2529-2534.
(18) Schein, C.H.,
Boix, E., Haugg, M., Holliger, K.P., Hemmi,
S., Frank, G. and Schwalbe, H. (1992)
Secretion
of
mammalian ribonucleases from Escherichia
coli using the signal sequence of murine
spleen ribonuclease.
Biochem. J.,
283(Pt 1):137-144.
(16) Schein,
C.H. (1991)
Physical methods and models for
the study of protein aggregation.
In: Protein
Refolding (G. Georgiou, and E. de
Bernardez-Clark, eds) A.C.S. Books
Washington,
D.C., pp 21-34.
(9) Palva, I., Lehtovaara, P.,
Kèèrièinen, L., Sibakov, M., Cantell, K.,
Schein, C.H., Kashiwagi, K. and Weissmann,
C. (1983)
Secretion
of
interferon by Bacillus subtilis.
Gene,
22:229-235.
(8) Weissmann, C., Nagata, S.,
Boll, W., Fountoulakis, M., Fujisawa, A.,
Fujisawa, J., Haynes, J., Henco, K., Mantei,
N., Ragg, H., Schein, C., Schmid, J. Shaw, G.,
Streuli, M., Taira, H., Todokoro, K. and
Weidle, U. (1982)
Structure and
expression of human alpha-interferon genes.
UCLA
Symposium on Molecular and Cellular Biology
XXV:295-326.
(7) Weissmann, C., Nagata, S.,
Boll, W., Fountoulakis, M., Fujisawa, A.,
Fujisawa, J., Haynes, J., Henco,K., Mantei,
N., Ragg, H., Schein, C., Schmid, J., Shaw,
G., Streuli, M., Taira, H., Todokoro, K. and
Weidle, U. (1982)
Structure and expression of
human interferon-alpha genes.
Philoso.
Trans. R. Soc. London (Biol.), 299:7-28.
(6) Weissmann, C., Weidle, U.,
Ragg, H., Haynes, J., Mantei, N., Shaw, G.,
Taira, H., Mishima, M., Boll, W., Schein, C.
and Fountoulakis, M. (1982)
Expression of interferon genes in
a heterospecific environment.
In
Humoral Factors in Host Defense, Takeda
Science Foundation on Bioscience.
(5) Weissmann, C., Nagata, S.,
Boll, W., Fountoulakis, M., Fujisawa, A.,
Fujisawa, J., Haynes, J., Henco, K., Mantei,
N., Ragg, H., Schein, C., Schmid, J. Shaw, G.,
Streuli, M., Taira, H., Todokoro, K. and
Weidle, U. (1982)
Structure and function of human
alpha-interferon genes.
International
Symposium for the Princess Takamatsu Cancer
Research Fund 12:1-22.
(4) Schellekens, H., deReus,
A., Bolhuis, R., Fountoulakis, M., Schein, C.,
Ecsödi, J., Nagata, S. and Weissmann, C.
(1981)
Comparative
antiviral
efficiency of leukocyte and bacterially
produced human alpha-interferon in rhesus
monkeys.
Nature,
292:775-776.
This site last
updated on 18 December 2012 by David Power.
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